My Two Cents:
Start with your desktop in easy reach of all else, BUT, also start with ultra long cables (within distance specs of course) so that once you are done with the near constant fooling with the PC while you set up, you can move it to a soundproofed, e-mag safe ( and still accessible occasionally) location, without rewiring it.
The long cables serve double duty, letting you behind the PC easily, and allowing the move later on. Wire is pretty cheap.
In my avatar pic at left, both Tracking Room PCs are in the left, underdesk bay, which is right next to the closet they will eventually reside in, the thru-wall port is already in place. Once there, I will soundproof as needed, there is crawlspace access for easy cooling if necessary, and I usually don't worry much about e-mag since I gave up CRT monitors years ago.
YMMV.