Probably distance and direction. In some audio/interface you would not want to use any Hosa cables, they get stuck in the Neutrick connection and can not be pulled out, and then when you paid a couple of thousands for the unit, you have to try and take it apart and may break the combination connecter or send in the unit to have them get the triangle shaped tip end out, because it is not rounded.
I have I think live wire cables, I have no problem with them.
Of course I have some others also from Sweetwater, but since they all cost about the same, I can not see where that would be a problem. At least with anything I have, it is not.
Could be electromagnetic interference, or poor shielding in some unit that picks up the interference (radio frequencies). Always getting bombarded by electromagnetic waves all over in the atmosphere, or if close to a high-power voltage line can cause problems also.
Most people use a power conditioner for the power supply also, because of dirty power or brownouts with power (or even blackouts) and also may have a uninterruptible power supply to shut down things safely if power fails.