One of my biggest surprises when we arrived in NY was that they sold wine, beer and cigarettes at the pharmacy.
Plus, in Quebec, you can't buy alcohol after 11pm (except in bars, of course). So when I saw that guy buying a 6 pack and a pack of cigarettes at midnight at the nearest CVS, it was probably the biggest "cultural shock".
Also found it weird to see that WalMart was selling alcohol, here. But, hey, if the mission truly is to be a one-stop shop...