I don't want to tell you to fall back to 32 bit. If you can work with it some more, maybe it will work at 64 bit. I looked at a couple of the Dell drivers (SigmaTel and Intel chipset driver) and both will support Vista 64 bit. Thus, even though Dell officially does not support 64 bit it appears the drivers (or some) are 64 bit compatible. I used to do user support on the Dell forums (for 10 years) and It was hit or miss on whether users could make 64 bit work on systems that Dell did not officially support (same way with usupported Operating Systems).
First thing to do is make sure you are using all the Dell drivers. Windows will install some device drivers but they may not be right or the best drivers. On a new install the correct and required install sequence for a Dell is (1) Install Windows (2) Install Dell Desktop or Laptop System Software (3) Install motherboard chipset drivers (4) Install device drivers including Video, Dell Sound Driver, Touchpad, Ethernet and Wi-Fi, etc.
The Wi-Fi brings up another point. Wi-Fi is known to cause latency and sounds popping and crackling in many systems. Disable the Wi-Fi in the Device Manager and then run the DPC latency checker