I use small (20") display monitors because larger ones would intrude into the line-of-sight for the speakers. I've got them pushed back as far as they'll go before falling off the back of the desk. Someday I'd like to build a custom desk with a low shelf below where the screens could be set, angled upward and glass-covered like you'd see on a television news desk.
But even with the small displays and far positioning, I still have to set the speakers further apart than the usual recommendation of 3 feet. Mine are a little under 4 feet apart. This results in a practical problem, which is that I can only achieve the equilateral triangle by pushing my chair back about 1' from the desk. I deal with this by making a point of periodically listening (with eyes closed!) to the mix in that pushed-back position.
One problem with setting your speakers wide and toeing them in is that they don't blend acoustically in the manner you'd want them to. The further apart they get, the more like headphones they become. But without the benefits of headphones, e.g. eliminating room acoustics. As the speakers get closer to pointing directly at each other, you'll start getting phase cancellations between them that can skew your spectral perception.
You'll also have a less-than-ideal angle of incidence to your ears, which are physically designed to capture high frequencies from the front rather than from the sides. (That was once important in our evolutionary past, because it's crucial to location perception - a good thing when you're hunting for food in the jungle while avoiding being something else's lunch.)