There are a few other issues too with mixing on headphones. You will tend to hear the reverbs sooner and louder because the speaker system is right on your eardrum! You may hold back on them a bit thinking you have them right only to find that things are a little dry on speakers. One possible solution is to return all your reverb returns to a master reverb return buss and leave it set at unity say. Then when on speakers you might find you have to nudge that buss which has all your reverbs on it up 2 db or so maybe.
Stereo imaging becomes a little more pronounced on headphones too. Like things panned hard to one side really sound that way in your phones. There are systems
(hardware/software) that introduce precise amounts of crosstalk to remedy this. We also have speaker modeling devices that can simulate speakers in a room on your headphones. I have not worked with this technology yet. I know there are some forum members here that do use this setup and I welcome their input as to how effective they are. If you can switch your mix into mono before the headphone out, comb filtering issues
(from within the DAW that is not outside obviously) will still be revealed and can be sorted.
There are some great sounding headphones around. Listen to the advice here regarding makes and models. These forum members will cut to the chase and at least you know where to start listening from. Don't listen too much to the salesman either. Do not sell your speakers, it is silly advice.
I have got an old pair of Sennheiser eh150's and they sound like my monitors up loud! Sometimes I rip them off in the middle of the night thinking I must have my monitors on because the sound is so good but only to find that my speakers are in fact powered off and silent!
I know I rant on about a single mono Auratone type speaker down low. Yes it is also good for this scenario too. Because you won't disturb anybody with this either. If you are down to 75 dB SPL or quieter your neighbours won’t hear it. I have worked this way at all hours with no complaints. It stops the noise issue and you are still on a speaker and getting a more accurate speaker mix too. While you are sitting directly in front of a speaker like this (8 or so inches away) i.e. close to it and looking directly at it and it is soft in level, your room acoustics do not come into play. You can rule them out too.
You still need some quick checks up loud on your main speakers though for bass and reverb levels.