4 sticks "quad channel" most 2011 boards now have 8 slots for ram
2 stick means you are getting 1/2 the bandwidth as it will run in dual channel.
both 1155 and 2011 have PCIe to PCI bridge. as in NOT native anymore.
depending on what interface it may or may not work..
RME works fine in either
M-audio/Echo and few others probably not.. Lynx for the most part works.
PCI is pretty much dead at this point..