firebird is right about defragging. The process of copying your files from the old to the new drive will cause the OS to re-assemble any fragmented files and then write them sequentially to the new drive.
Cloning (depending on how it is done) might be a worse way of copying the files. A binary/sector copy could preserve some fragmentation from the host drive to the target drive. A simple copy will not do that.
Authorization preservation depends entirely on the method used by the vendor to prevent copying. Most authorization schemes are likely to detect that the samples have taken up residence on a new drive, and require re-authorization, regardless of how they are moved. Your best information for that would come from the vendor (if they are willing to provide that information to you) or from the experience of other users of the specific sample library who have tried a similar move.