@SCorey... No need to abandon your old i/o. Just slap it into an older system. My Layla will be going back to live in my old P4 again to run Nuendo. Then I'll have two studio systems. :-)

Yes PCI is dead, and firewire is on the edge. I have no experience with this hardware kludge, and have a fairly low opinion of the manufacturer in general, but it might work to keep an old interface doddering along. Maybe there is a better version about.
 
http://www.newegg.com/Product/Product.aspx?Item=N82E16815158165

@slartabartfast... Cakewalk tech support advised me against those FWIW.

Well, I use a PCI424 with a Sandy Bridge MSI based system with no problems, and now just built a Z77 Ivy Bridge machine for a Delta 1010. I'm sure there are some problems, but that's a super old PCI card with a brand new system and it works perfectly. Maybe I've been lucky.... R

Cakewalk tech support advised me against those

 
So presumably they have had some frustrated users calling.
 
This compatibility issue is one of the more important reasons not to commit to an interface that plugs directly into the motherboard. To engineer an interface to an external standard communication protocol you only need to deliver the data in the correct format and signal specifications to a plug of the right configuration. To make something work inside a computer of the future, you need to have enough space to fit it, the right power supply etc., AND you have to figure out what socket will be there before anyone has invented it, or some way to fit an adapter inside the case and drivers that will translate everything so that the legacy equipment sees it as if it were still plugged in to an obsolete motherboard. There are plenty of usable PCIe to USB and firewire adapters available, even though much of the external equipment that is connected to them was built during the PCIold era, and a pretty good bet that if PCIe is replaced, someone can engineer a new adapter to fit the new MB socket and put out USB or firewire data that will keep the external device happy. The tiny improvement in theorectical decreased latency by direct-to-motherboard audio interface connection is probably not worth the cost of trashing an audio interface that cost a couple of grand because some hot new MB socket has become popular.

There have been a lot of people on here having problems with their Delta 1010s so yeah, either you got a good board or you aren't demanding too much from the card. My Layla seems to be working okay now after lots of tweaking and jacking up the buffer but I'm sure if I pushed it I'd have problems again.

That Delta 1010 runs all day at 64 sample buffer size with high track count/high cpu load projects. From what I understand there were some chipsets with PCI bridge nonsense, but Z77 seems to work perfect! BTW, it was a Gigabyte board FYI.... R

Might be one of the PCI Sure boards or whatever they are called. Do you know if it has Native PCI support? That's the big difference. If it's bridged maybe it's just a superior bridge design or something. I've also seen people talk about placement of the PCI card on the board helping the bridge work better. I don't know enough about circuitry to understand how that works but I think it has something to do with proximity to the PCIe chipset it is being bridged to. Cheers.