I believe RME and Lynx...two top end companies still make PCI card interfaces. Also the custom builders (that frequent this site) use motherboards with PCI slots in them, with current processors, etc.
I was just looking at Echo's site today, as I own a 3G (after a Gina and two Layla20) and want to upgrade my setup all around and am trying to decide if the 3G is in the game plan. Should StudioCat or ADK makes a custom build, then, my question is answered, as mentioned their motherboards have at least one PCI slot.
I've only read a lot about Echo products, since I've owned their products, but have nothing to compare with. But reading I've always got the impression their drivers are top notch and the audio quality is equal to stuff costing twice. But admittedly, wondering if the RME Hammerfall stuff would really make a difference.
Btw I NEVER use the preamps on any of my Echo stuff, and actually wish my 3G didn't have input 1/2 on the front with those cheesy knobs. I've tried the preamps with some mics like a Beyer M160, and they didn't have enough gain to cut it with that mic. That and other reasons lead me to believe outboard pres will ultimately get the best sound and choices. A good quality hardware chain into a decent card seems to be the route.
Then there's the Dangerous D summing box coming out of the computer.........