I have spent quite some time in attempts to run Sonar with Wine.
Current state:
* X2 works out of the box
* X3 also works
* Plat - NO go. Note that technically it can run, when in Demo mode. I personally blame authorization system.
Other DAWs (personal experience):
* Ardour is Ardour (Mixbus has the same engine). Works, but it is not a competition for general purpose DAWs.
* Tracktion Waveform. They also have FXes and Synth which run on Linux natively. Well, should run. After they have released Waveform 8 (and I have bought it), they basically have not managed to make it work under Linux... Simply do not care or with silly explanations why ("it works on our test system", "hard to find", etc.). Note that some bugs was plain simple, like exchanged in/outs. Finally they have fixed some of these bugs, but I have lost trust in what they are doing (no plans to upgrade).
* REAPER by tradition works under Wine and does that well. It is semi-supported platform. Linux native port is long time Beta("Experimental builds"). Every REAPER update is also available as native Linux. I guess the developers simply do not have the feeling it works with production quality (unlike toys producers at Tracktion, for which "can be started == can be sold"). But there is some recent movements, like a dedicated board on forum.
The most problematic part are drivers (for everything). Curiously, Roland/Edirol interfaces have drivers (including declared out of life VS20).