In one of the 'Under Review' documentaries, they go into his setup a fair bit. The biggies are:
1. Custom made guitar, with pickups that were popular in the 50s with British Invasion and Surf type bands often, nothing like modern ones.
2. He used a six pence I guess it was, for a pick, which has a serrated edge and is quite small and of course very stiff, so he would have been picking very close to the strings with a serated metal pick, which is going to sound nothing like a plastic pick.
3. Vox AC-30 wide open of course. You can hear the huge hum in the example videos above.
4. A treble booster pedal for leads often.
You can buy a repro of the guitar and treble booster, if you really want to go there. He had phase switches for each pickup on that guitar I think, so he could get various in and out of phase settings and often use out of phase on the middle and kneck pickup for leads, for that fat, screaming sort of tone, with the treble boost often to drive the AC-30 even harder and to get more top end.
A dime might do well enough for a pick that would provide similar effect. And you can hear that hard scraping attack quite a lot that you would only get with something like that.