Thanks for the feedback thepogue, I appreciate any advice or observations.
Sometimes I get into the habit of setting up certain instruments in a specific way, and generally speaking I like to give my songs a live feel to them, like you're listening to a band in a bar or garage. I enjoy the loose Grateful Dead, Neil Young, CSN&Y live feel in songs. And I usually start by giving the drums a specific reverb that I like (Breverb2 -> Drums -> Alive). If you ever watch a movie and there's a band playing in the next room, you get this type of reverb sound if you bring the wet level all the way up. I bring it about 1/4 of the way up.
For other instruments, I usually add a touch of reverb or delay or chorus, depending upon the instrument.
The only thing I like to keep really tight is the bass guitar and drums. Otherwise the song ends up sounding not loose but sloppy.
And as I mentioned in a previous post, this was one of only two times I've used a lead guitar loop for that instrument. Usually I'll play it myself using any one of my VSTi guitars. But I wanted something fresh and different sounding for this song, and I chose this loop from a set I got at BigFishAudio. It took a while to find a lead guitar loop that fit the song, this one came the closest. But again, you're not the first person to point out that it doesn't sound like it quite fits.
Anyway thanks again for the feedback, it was all very helpful!