Yeah man, it will definitely require experimeting and really honing in on what you think you are hearing. For example, let's say we ran the Saturation knob first in the chain and we used "keep high" setting on a drum kit. And, lets say we put a compressor like the pc 76 after it. Turn the compressor off for now. Now set the Saturation Knob to about the 8th dash which is about 1:00 and listen to what it does to the drum kit. Now turn on the compressor and mess with it.
You will notice that the more you mess with your compressor, the more it controls the way the Saturation Knob effects your sound. Add an eq after the compressor (or before it) and the eq will literally control how the Saturation Knob behaves tonality wise. If the eq was BEFORE the Saturation Knob, you wouldn't hear it actually messing with the sound of the Saturation effect, understand?
The compressor after the Saturation Knob (when the right attack and threshold is used) will smooth the effect out (as well as your drums). If the Compressor was before the Saturation Knob, it wouldn't smooth out the Saturation....it would just effect the drums. So with the compressor after, it compresses both the Saturation Knob and your drum kit. Compressor first, just your drum kit and the Saturation Knob will do its thing without any smoothing. Understand now?
The same thing applies with other effect. It's like....if you want to compress your effects you are using, you put the compressor at the end of the chain. If you want to effect your compressor, the effects go AFTER it. They will all still process your track you are listening to of course, but the order you select will dictate how things sound.
Another quick example. I like to use a compressor on my bass followed by a tone coloration EQ (like the UAD Helios) and then a Sonitus to high pass the bass. I use them in that order. Now, there are times where the bassist may need a little help. So moving the compressor to last in line will give me a totally different outcome and will compress the tonality eq as well as the high pass eq. This is a more aggressive approach where normally, I wouldn't want my eq's compressed...just the bass itself, so the compressor would be first in line. Get it now? :)
The same thing with enhancement effects. Do you want to delay your chorus, or chorus your delay? Do you want to flange your panning, or pan your flange? This is why effects order can make a cool difference. But it's something you'll need to experiment with for sure. Like I said before...sometimes it's a subtle difference, other times, like where I have to change my compressor to last in line on my bass track, it's more drastic in the change because then I'm compressing my bass as well as the eq's that are before the compressor which opens up new sound options. :)
-Danny