I have heard demonstrations of hex pickups played live through six amplifiers in a semi-circular array, and it sounds very cool indeed. (My generous benefactor who's got me into NAMM year after year has been a German manufacturer of acoustic guitar pickups.) With a pickup on every string, you can play the guitar normally so the performance doesn't sound weird or artificial. It is particularly conducive to finger-picking.
Lacking such a device, the next best thing would be to use a sample library. Guitarists might well wonder why on earth they'd ever buy a guitar library, but this is a good example of where it makes sense. Assuming, of course, that you have the keyboard chops to pull off the guitar parts on keys. (A MIDI guitar would, I suppose, be the best of both worlds.)
Once recorded as MIDI, you can split the performance into multiple tracks and do anything you like with them. Not just pan them separately (e.g. low notes in the center, high notes hard panned), but also have separate effects. You could put more reverb on the high strings, less or none on the low strings. You could put a chorus on just the low strings. You could brighten just the low or just the high notes.
I do something like this now with piano. After recording the piano part (as MIDI), I'll split the lower and upper parts into two MIDI tracks and pan/EQ/effect them separately. This lets me automate the left- and right-hand parts independently, which is very useful as the left hand is prone to getting in the way of other instruments. The same could be said for acoustic guitar parts, where sometimes you want the low strings in there and sometimes you want to back them off for clarity in the mix.