Clapton did this on the 5/4 intro to Creams "White Room".
If you play the notes of the triad inversions separately you get a very different sound than strumming them together.
The overdrive/distortion sounds very different when you play the notes separately. It's a fun thing to play around with.
When demonstrating dual lead guitar part to students I've often played both simultaneously to demonstrate the effect. It's fun to work out a way to do it, but sounds completely different to double tracking the parts. Imagine the possibilities if you track the three parts (triads or partial chord) on different guitars/pickups?