More info please.
Computer OS.... version of the cake product....
I've heard that firewire is going away and USB seems to be the enduring standard... for now.
The Presonus will work, you just gotta get it set up right.
If you can hear other things playing thorough the Presonus, you know it works.
Can you hear PLAYBACK of your Cakewalk product through the presonus? If so, you simply have some setting not set properly or levels are down in the chain.
I also notice that from time to time, something in my recording rig gets ..... "misdirected" and I get no input from my Saffire interface. I can hear playback just fine BUT... my meter indicates nothing, I get flat line recordings and looking at the settings, they are all correct.
I re-boot the computer after a total shutdown. Computer & interface. After the restart, communication is restored and it works again. Be sure to try that.... fresh cold boot when in doubt.
The other day, after doing all that... I had just deleted 2 envelopes and then edited a track to move one clip to the second track..... I was getting no sound from the second track after dragging the clip in. Not just the clip but the whole track wasn't playing. After a reboot (cold) it still didn't work but I could hear the other tracks just fine..... I discovered that the clip had the volume pulled all the way down..... sometimes it;s just the simple things.