I read 2 distinct subjects in this question..., and then the undertone. The craft itself and what it has to offer (theory) and the mastery of the theory through practice (skills).
At a fixed point in time, a craft may seem to have a finite amount of theory to offer and some may feel that their is no more to learn, but can you say the same about the skills? And as your skills grow along with your understanding of the theory, wouldn't it be normal to touch/transform the theory with your own discoveries through practice, hence growing the theory further, where it may actually become a subset of the original craft demanding a new set of skills to master? Isn't this part of human nature, hard coded in our genes? I believe that if theirs no more room for learning/growth/renewal/reinvention or desire for such..., I might as well be dead.
On a more non-esoteric note, I practice my instruments on a daily basis (just about) and it's not easy. When I was much younger, it's something that I had to do, being completely helpless in the matter (discipline was not an issue). Now it's a different story. And it's not because I don't love doing the music, but I have to admit that the flame, even though still burning, is not burning as hot as it did many years ago. I cannot play the music if I don't feel it, and practice helps me in this regard. That's the motivation I use these days to discipline myself. I still feel that there's also lot's to learn, but in my case not enough time in this lifetime to even make a noticeable dent in the mastery of this craft. There's always going to be more to learn and through practice..., master. And besides, I have no doubts whatsoever, in my case at least, that the journey is the real challenge and reward, all at the same time.
On the undertone...
I do believe that whenever someone feels like theirs no more to learn (regardless of the craft), that it is simply due to the fact that the interest in that particular craft has dissipated/died, which is the case for many (and that's a sad state of affairs especially when so many years of effort have been invested in learning the skills). But that's a reality that some of us face, sometimes more than once in a lifetime. It's not a terminal condition. It's part of the renewal process which some of us have the chance to experience more often than others.