If you want to mix in 5.1 surround you will need an interface with six analog outputs (unless you have digital powered): A) 2 for right and left (mains); B) 2 L & R rear satellite monitors; C) 1 for the center satellite monitor; 4) 1 more for a subwoofer (optional).
You could use any speakers, I guess, but if you are going to mix then I suggest reference monitors (which are sold individually). As for USB interfaces, here are a few from cheap to expensive to much more expensive: Behringer FCA610 ($200); TASCAM US-1800 ($200); Steinberg UR28M ($400); Roland Octa-Capture ($600); Roland Studio-Capture ($1000); Focusrite Scarlett 18i20 ($500); MOTU 828x ($850); MOTU 896mk3 Hybrid ($1000); MOTU 1248 ($1500); RME Fireface UC ($1400); RME Fireface UCX ($1600);RME Fireface 802 ($2000); and then there are those that are over $2000 from makers such as Antelope Audio, Prism Sound and Lynx (which may require additional hardware), just to name a few. Some of the above mentioned interfaces have more than enough features for your needs, but I did list those that meet the minimum as well (eg, six analog outs).
Kind regards,
Living Room Rocker