The act of mixing multi tracks down to 2 tracks is a form of additive synthesis and so there will always be phase "issues"
What to look for?
One easy too recognize circumstance is that you may notice an occasion when you turn something up and it gets quieter. If that happens you'll want to look for something that is 180* out of phase. This is also known as reverse polarity and it can cause nulling or loss of amplitude.
Other small phase issues can cause a thinner sound than you expect... this can happen when very similar tones have slight timing differences. This type of phase issue causes nulling and peaking at frequencies specific to the circumstance.
Many times, phase issue occur because of bleed in microphones from a multi track take. The same symptom of thinning and perhaps fluttering is realized. You may observe this on tracks of a live drum kit. The sounds from each drum reaches all the microphone in varying degrees of amplitude. The sounds get to each mic at different times becasue they are different distances to the drums. Most people learn to place the mics to avoid the worst effects of phase cancellation.
With regard to drum samplers... it's hard to say. It really depends on the actual and specific sample library and how each and every sample is prepared. It also has a lot to do with the sample libraries mic set up... some feature "bleed" and most do not.
With regards to soft synths. A synth uses synthesis... and is almost always purposefully manipulating phase in an effort to sculpt a complex timbre out of a basic tone.
That's a start... there's plenty of other ways to looks at it... there are meters, analysis, stereo to mono issues, etc. etc.
I wouldn't worry to much if you aren't hearing something that bothers you.
best regards,
mike