You may get some earth grounding hum. Here is a relatively new device which is designed to solve the problem if that is indeed the case.
http://www.sweetwater.com/store/detail/DTI It is so new it is not even on the ART website yet as far as I can see. It has got RCA, Jack and XLR inputs and RCA, Jack and XLR outputs with high quality isolation transofrmers between input and output. This would be a worthy device to have in any case.
Impedances may effect you as well but if the output impedance is low from the mixer then it should not be an issue, earth loop hum might well be your enemy in this situation.