Hey, this is a bit different for you... It still has your rock-funky grooves and riffs, but a little more eclectic in some way. The change-up in chord progressions between sections is really cool. And yeah, you definitely get some good use out of those amp sims, and FWIW, you should add synths more often.
The mix sounds good from here, maybe a little left-oriented in spots, but still great separation and clarity.