Some people swear by trackballs, other people hate them. Maybe it has something to do with the size and shape of your hand. I used one for a while a few years ago and loved it initially, then after one particularly epic Photoshop/Lightroom session I realized that my hand hurt like buggery. It was all seized up. I trashed the trackball the next day and went back to a regular mouse.
Another option of course is the vertical mouse, these are (purportedly) good if you have tendon problems as they force the arm and wrist into a less damaging position. I used to know a woman with crippling tendinitis and she swore by hers.