ok... I'll bite...
Can't replace my ARP 2600 - tried the Arturia, did not like it, tried the TimewARP, loved it, but it is not quite the same, so I'm keeping the hardware.
Can't replace my MS-20 - I have the Korg plug-in, and it is cool, but it is not the same.
Still have found nothing that sounds like the Ensoniq ESQ-m or the Roland MKS-80. I would love to find something to replace these. NI FM-8 is really close, sometimes even better, than the TX7, but I have not been able to reproduce some of my favorite TX-81z patches yet.
The Kurzweil 1000PX - no, not terribly realistic, but terribly cool, and I've yet to find a replacement.
I am happy with a handful of EPS/ASR and S900/S1000 libraries that I have successfully imported into Kontakt, but it is a LOT of work to import them. It remains quicker to just use the old samplers.
Other than that...
I'd say the old Pro-53 does a great job of covering various Sequential sounds. If I could get another Prophet 5 I'd probably buy it<G>!
The Oberheim Matrix/Xpander family - I can't find anything that covers them, but all I have is the Matrix 1000, and frankly, it doesn't do a great job of covering the Xpander either<G>!
So... fire away! I'd love to empty another rack or two, and put it all up on eBay (well, except the ARP and Korg<G>)