If I were buying today, I would opt for USB since that has come along nicely, is faster than FW now, and is more widely compatible. There are some folks who experience chip compatibility issues with some FW chipsets. That's not an issue on USB. Just to say the latency and performance is still better with Firewire than USB 2 (firewire 400 is around 25% faster apparently, although take that with a pinch of salt), and even better if you only have one device running one dedicated interface. If there were any USB 3 interfaces available than sure USB would be faster than firewire, but then Thunderbolt could throw a spanner in the works... one day....
In the real world firewire is without doubt faster right now.. Maybe not for very much longer...
My Firewire Saffire Pro 40 is running on an ASIO buffer size of 128 right now, I may risk 96 soon.
Thanks
Here's a Focusrite article:
http://uk.focusrite.com/news/which-interface