Sure, 3 D is what the joystick is all about. And the reason it is less controllable. Better for smaller control increments and experimental things. If you just want to alternately control mod and pitch, wheels are your best bet for traditional sounds. But put a single pitch step across one axis and do micro bends. Then do the same w/ filter resonance on the other axis. Drone away, bro, drone away!
That being said, I'm sure one could get good w/ more traditional control if you worked at it.
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