Hi Mesh  I don't think Midi Guitar actually installs. I have deleted The files and unzipped and then tried to run them. The Plug-in works in doth 64 or 32 bit but the stand alone only works in 32 bit. It worked several weeks ago and I do not think I have had any Windows or other updates since I last ran it. 

That's really strange.....especially, if it worked in the past.
 
I don't know if this makes a difference or not, but I also make sure all my stand alone VST's (including Midi Guitar) match my 2i4 at 48kHz. Other than that, I really don't know what else to suggest......I would've done the same things you've already done. Very strange indeed...

Mesh
Very strange indeed...

Typical

bapu

Mesh
Very strange indeed...

Typical

Most peculiar mama

Maybe this is why it is still in beta. Make sure to report any problems to the manufacturer. FWIW, no crash in 64bit stand alone here with one interface, a Presonus 44VSL running an older driver on Win10. Clicking the interface entry in MIDI Guitar brings up the interface dialog OK.

 
Thanks Scook. I have tried running it as admin, closing everything I could find including antivirus. It is odd that this version has worked in the past but not now. Previous versions do not work either just vst or 32 bit stand alone. I shall report and see if Jam Origins has any ideas.

 
The case is solved. It was indeed a mismatch between Midi Guitar 64 bit and the audio interface. Of course there was no way to know that since I could not open the 64 bit app. I opened the 32 bit changed the sample rate on the interface and the 32 bit app to 44.1khz, closed the app tried the 64 bit it opened and allowed me to switch everything back to 48khz. it now opens and functions as it should. Thanks for the clue Mesh.

Glad to hear it worked out Dan.
These kind of things really bugs me if they don't work as intended to......this forum has saved my behind many, many times. :))