I'll reseat everything later today and let you know. there is no dust in it, the case is filtered (filter is clean) and it's just been built. I really doubt it's overheating, I've never had an issue with any other computer in the same spot, so airflow shouldn't be a problem.
I was almost leaning to the motherboard was shorting out. It's funny that it runs no problem on it's side, but then as soon as you stand it up that's when there's a problem. I also have an aftermarket Cooler Master heatsink on the processor, so I'm wondering if maybe I didn't seat it properly. But, it seems to be on there very well.