sharke
I think a lot depends on your guitar and playing style. For me and my Telecaster neither Guitar Rig or TH2 has wowed me as much as Amplitube Fender (or the Orange and Dr-Z amps I've added to it), but I've been wowed by them after hearing different guitars through them. Having said that, I still use Guitar Rig and TH2 for the effects and stomp boxes - you can get some insane chains going in GR and TH2 has an awesome tremolo pedal I use all the time.
I'm all on the same page as Sharke.
I'm wowed by Amplitube. There's a summer special going on now for just another week or so where you can get all the offerings for Amplitube for half off. It's a great deal. As Sharke says, with Amplitube, the Fender add-on, Orange, and Slash the sound is really terrific.
That said, like Sharke, I use Guitar Rig 5, PodFarm, and Th2 as well for various things. But for me, Amplitube is my go to for sure. There's also a very helpful amount of free tutorials on it, and an excellent one on Groove3 - all of which improve getting the most out of it.