I think a lot of people have bought into the hype from manufacturers about emulation instead of simply evaluating products on their own merits, for what they do.
Nothing creates the sound of a tube amp better than a...tube amp. This shouldn't come as a surprise. However, no tube amp can create the sounds that are possible to obtain with amp sims. Nor is there any law against using amp sims with physical cabinets or tube pres with virtual cabinets.
I ditched guitar amps decades ago and went for FRFR keyboard amps and/or PA systems because I didn't like the sound of guitar amps, except for specific applications. Also I could have much more fun with feedback because I could almost "tune" it, which I couldn't do to the same degree with amps. The reason why I started designing my own effects like the Quadrafuzz was to create sounds that translated well over FRFR systems.
However, the fact remains that a guitar amp is a very complex and sophisticated signal processor; when you want
that sound, an amp will do it best. So, for those applications I have a versatile Line 6 DT25, a Peavey Windsor (which is very tolerant of tube substitutions), and an Orange Tiny Terror that kicks butt. For the sounds I hear in my head, I have amp sims.
To me, there are only two elements to the debate. Does an amp sim playing back at moderate volumes through studio monitors give the same experience as standing in front of a stack of Marshalls? No. Can a stack of Marshalls make the sounds I really like that are based on amp sims? No.