I ran a simple test.
Correction : The Alesis multimix only has SPDIF out, no in.
I connect the coaxial / RCA cable from the Alesis SPDIF out to my Quad Capture SPDIF in. I feed the Alesis with 2 tracks audio (left/right).
The Quad Capture line out is removed for the test - and I monitor via the headphones. At first I did not get any signal from the Quad's SPDIF in.
I have to start Sonar->Preference->Device and check the Quad Capture's input/output 3 and 4.
After that the Quad works fine, picking up the audio signal via it's SPDIF in. One thing to note is that input volume depends on the Alesis main mix level.
I've also reboot my system and the Quad's SPDIF continues to pickup the signal without having to do further setting on it's driver.
Also, I've been running all my audio at 44100 sampling rate, 24 bit. And the Alesis is running stand alone (not connected via firewire).
So, the Quad is now operating with all 4 ins.