Anderton
To quote Herman Cain "I don't have facts to back this up," but I tend to think of open region FX as clips being in a state of suspended animation. I like to bounce them to clips and return them to the real world once I've done the required processing. I used to keep safety copies in case I changed my mind, but never went back to them so I got out of that habit. If something needs to be re-worked, I re-cut it.
Yeah, I'm kind of getting there myself. I've developed this DAW inspired never-throw-anything-away philosophy that is useful far less than I expect it will be. I had actually already rendered the track some time ago and archived the one with Melodyne in it, but I was keeping all of the constructive work product - vocal comps and takes, Melodyne edits, y'know, just in case...
Remember when hitting the record button was always a commitment and there was no such thing as non-destructive?