Certainly
17 VI's: Raputure, Dimension Pro, Stylus RMX, Trilian, PianoTeqProject was running fine with very low latency with all these on for the past several days. Latency occurred today so I froze most all of them. Latency still here. This happens every now and then and rebooting the machine always fixes it, but not this time.
Stereo bus:Prochannel compressor and EQ
Ozone 4 with all modules except stereo imaging. (no improvement when off)
K Meter (no improvement when off)
Reverb bus:Pantheon (no improvement when off)
Tracks:About five tracks with Prochannel Compressor and EQ (no improvement when off)
When I press "E" to bypass plugins, latency goes away.
I know there are a few VI's I'm not actually using, so I'll go through and pull those out.