Sharke you need to read that thread:
http://forum.cakewalk.com...-bigtime-m3046633.aspx In short it depends.
Craig started out by comparing a virtual instrument being rendered at 44.1K compared to upsampled to 96K, renederd up there and then down sampled to 44.1 K again. He was expecting things to be similar but found the 96K version sounded better.
It depends a bit on the synth and the sound it is making. If the sound is very warm with little high overtones and it is coming from a great analog synth emulation, then maybe not so much. But if its 'Prism' making a very complex sound with lots of activity higher up and lots of interesting detail up high, then yes the 96 K version sounded better and I heard it as more natural
(smoother, less of it but more worthwhile) top end that was better balanced. ('Prism' is still producing activity as high as 48KHz!)
Now this is also assuming you don't put any VST's into higher precison made which some can do. Some can internally up sample and do their thing and come out at the normal sampling rate. Put them into that mode prior to mixing and render that way for best results if they can. If the VST cannot do it then you have the option of creating a synth render session at 96K and render at that rate instead.
(You transfer the midi tracks from the 44.1K session and create a new session at 96K. Setup the same virtual instruments and play back all the parts at the new rate. Gnerate 96K renderd versions of all synth parts. Then downsample to 44.1 kHz and insert in original session.) Converting sampling rate down to 44.1K Hz seems to retain all the smoothness and value from going up to 96K and back.
Meaning 44.1kHz and 16 bit is an excellent playback medium. We just need to work at higher precisions prior to generating our final playback medium.