I'm not sure about WDM - with MME you can use two different units at the same time.
ASIO drivers only allow one instance of a driver, but some manufacturers write their ASIO drivers so that two of the
same units can be used at the same time. For example, I can run two Layla3G units (for 16 channels) using ASIO on my mobile DAW. As far as your UA101, you can either ask Roland, ask in a users group, or, since you have a second unit available, just give it a try.