You might find this workflow easier:
1. Insert the plug-in and set it up as desired.
2. Save your default settings as a preset from the effects window’s top toolbar: double-click in the preset name field, type in a name like “Default Settings,” then click on save (the floppy disk icon).
3. Choose Utilities > Cakewalk Plug-in Manager.
4. Call up a Layout File containing the plug-in whose default preset you want to load. Note that each plug-in can have different default presets in different layouts.
5. In the layout’s plug-in tree on the right, find the plug-in from step 1.
7. Right-click on the plug-in name and choose “Properties...”
8. In the properties dialog choose "Default Settings" from the Default Preset drop-down menu.
9. Click OK, then save the plug-in menu layout you selected in step 4. When that layout is open, the plug-in will open with the default preset when inserted.