16 tracks should not be an issue with those PC specs, but the number and type of plugins could be a deal breaker, depending on what all you are running.
If you are using any plugins with linear phase, such as Cakewalk's LP-MB or LP-EQ, they must be used in non-linear mode while tracking or mixing. Linear is best used when doing your final mastering.
Some plugins could just be very CPU hungry, in that case you could bounce down a few tracks to lighten the load.
Or try disabling your plugins, and then enable them one at a time while observing your PC performance. Maybe you can identify some that are causing your issues, and if any of them are particularly troublesome in your rig, then you might try a few alternatives.