Tessalator
I'll check out the virtual midi-cable; sounds like an option.
Beepster - on the detuning, I'm just detuning a few cents. Basically like double tracking or when you tune a piano. You don't tune all three strings exactly the same. Just being a tiny bit off really fattens the sound. (I was also looking for a plug-in that dynamically and randomly shifts the freq and timing just a touch to emulate double tracking)
The overhead was on me, not the PC - I'm too lazy to copy and paste!
My PC is pretty massive.
Hmm... well a lot of those synths are tweakable so maybe you could fiddle with them to fatten things up and you may be able to use the multi outs on some of those synths to just use different variations of the same patch (I don't know enough to say if this is possible nor would I know how to set that up).
However as far as the copying you could just Right Click/Clone the track and it will set the whole thing up for you again (and I think create a new instance of the synth). Then just change the synths settings on the new tracks. If resources are no issue then it should be fine.
I'm not a proficient synth guy yet though so those are mostly theoretical guesses. Cheers.