Maybe everyone already knows this and I'm late to the party, but I stumbled on this technique by accident and it's pretty mind-blowing.
I was recording an audio example for gibson.com of how to use the QuadCurve EQ to shape the piezo sound of a J-35 acoustic guitar. The audio example involved strumming chords (no arpeggiation, single notes, etc.) - the kind of rhythm guitar part you'd play behind a singer/songwriter.
By creating a Region FX and invoking the Percussion algorithm, I can transpose an individual chord as one "unit." It's not the same as polyphonic mode in that the notes aren't broken out separately, but I was able to transpose individual chords and entire tracks up and down 4 semitones with acceptable audio quality. After that you start to get the Darth Vader/Mickey Mouse effect, but in many cases it's still useable.
So yes, you read it right - polyphonic acoustic guitar rhythm track transposition with Melodyne Essential!