I guess it depends whether you are likely to want to re-visit it. I have found that I can leave quite a lot of melodyne clips open in a project without any issues, but I also prefer to tidy up as it were, so first off, I clone the track before making any changes and then mute/hide that one so that I have the original if I mess anything up. I set up Ctrl+B as a short cut for bounce to clip, so when I'm done with the changes, Ctrl+B and it renders the changes.