Over at Gearsluts, lots of people were complaining about the driver not working with USB, I mean a lot of complaints on both sides, Mac and PC. And get this, most of the issues are from Mac users. Lol.
So in the beginning, a lot of people who work in big studios were using the Orion 32 via Madi. Perhaps they already have the card, and some fork out $1700 for the RME Madi card, or less than $1000 for the SSL Madi card. But the majority were buying or using the RME card, because of their low latency.
This is the main reason I waited and waited. There is no way that I would spend $3000 for the Orion 32, not counting another $1000 for cables, since they use d-sub cables, and you would need a minimum of 6 at $150 a piece to work with the Orion 32, and spend another $1700 for the RME card. The card would be then like 50% of the cost of the Orion 32.
To answer your question, I use it via USB, and I still get that incredible latency as I said earlier in my post above.
If you use it with a laptop, make sure you have a fast one. But I think you should be fine.
The reason the Orion 32 works so well with USB is that Antelope desinged the chip themselves for the driver, but someone else wrote the driver for them. And the company that wrote the driver is a top notch company in Europe. But it is the chip that makes the whole thing works well over USB with such high track counts.
I myself was very surprised about how well it works over USB with such high track counts. They did it. You only see this with Antelope and RME so far, I think. Remember again that this is not merely a 8 channel box.
dan