Some wistful ponderings:
I use a UA-4FX for my lappy and it is finicky. But I believe your specs are reasonable. Albeit, 7200 internal HD is about mandatory, iirc. SSD is better.
1) Experiment with the ASIO buffers as most may not work.
2) Make sure your USB card has all its switches correctly positioned.
3) Make sure your USB card uses external power if required (albeit some cards operate reasonably with USB-3's power (900mA, iirc))
My current lappy (Dell XPS 15) only works with 1 ASIO setting. Sometimes I have to reset things to that specific setting.