In case this is at all helpful: I have the original version of Alesis iO|2, and it's working fine, EXCEPT its driver doesn't work with 64 bit. A couple of years ago I begged Alesis for an updated driver, and after some dancing around in their replies, they finally said the unit only had one driver ever released for it, and no update was available. They also admitted the driver doesn't work in 64 bit. Their official solution was to use ASIO4ALL.
So, that's what I have set up, and having the two different drivers hasn't caused problems I'm aware of. When I open Sonar 32 bit, iO is the driver that comes up. When I open Sonar 64 bit, ASIO4ALL kicks in, and its the driver listed in the audio dialogue. If, when Firefox is open, I open a stand alone version of something that needs audio, like the ARIA Player stand alone version, that's also when ASIO4ALL kicks in, because Firefox usurps the Alesis ASIO. It's the same scenario if I open Sound Forge when Firefox is open.
If I'm working in Sonar, using ASIO4ALL, naturally that's the interface that opens when I click in Sonar's audio dialogue to adjust the interface latency settings.
For me, going back and forth between those two drivers, depending on the situation, has been pretty much seamless.
Randy