Anderton
Line 6 uses what they call "Tone Direct" technology which indeed gets extremely low latency because they're basically bypassing all the layers most interfaces go through. ..The tradeoff, though, is you're committed to recording whatever sound you've dialed up with their POD software.... Still, Line 6 came up with a viable latency solution at a time when computers often weren't up to the task. I still have my KB37 :)
Well, I don't know how it's done, and I'm aware of the Tone Direct selling point on the KB-37, but I'm now using Amplitube for my amp sim. Although I had some great tones from PodFarm and GuitarRig and TH2 I've migrated to Amplitube because it's very good.
As usual, when I record, the tracks are recorded plain and dry. While I'm playing / recording, however, I'm getting the full blown Amplitube effects with no perceptible latency, even with lots of audio tracks engaged. There's absolutely no tether to The KB-37 for the sound. It just works great. I use my Focusrite audio interface for everything but tracking / recording individual guitar and vocal inputs.
The Focusrite, which is a rock solid audio interface, is just not able to pull off the non perceptible latency to the same degree - at least when a song is loaded with a lot of tracks.
Just pointing it out in case there's a forum user interested in seamless playing /recording especially for electric guitar, vocals, and acoustic guitar. I know it's not a mainstream idea, but it works really well with no perceptible latency. It works like you want it to.