A bit of explanation...
At present I have a bunch of hardware synths connected to a Mackie mixer which in turn feeds two pairs of UA-101 line ins, plus one UA-101 in/out pair acting as an aux bus for an external fx unit I sometimes use on anything from one track to a complete mix.
Ideally I'd like to remove the mixer and the fx unit on the Mackie's aux bus which provides a basic delay and reverb and connect everything direct to the interface then monitor via Sonar, thereby making vst effects available while tracking (if I can get latency low enough).
My comment about ADAT isn't because of any prejudices or desire to avoid ADAT in principle, simply that ideally I'd like to only have one box to power rather than two, thereby saving space and power sockets.
To be honest I'm not 100% commited to removing the mixer etc., because there are issues with direct monitoring just as their are (different) issues with my current setup.
Thanks for the suggestions - I've been considering the MOTU unit + one one of their preamp units and ADATing them together. I'd not spotted that Tascam make interfaces with that many ins/outs though.
Time to do some more thinking........