Guitarpima
I read Dan's blog on de-essing and have to wonder why do it that way? It makes sense but why do it that way?
Sometimes you need to make the 5 PM Fed Ex dropoff
I get side chaining but never saw a use for it other than voice overs.
I use de-essing with guitar prior to going into an amp sim. It's like a more "intelligent" version of rolling down the highs with the tone control to get a creamier tone. However, I tend to use a multiband compressor, with all bands except the high frequencies set for no compression. That way I don't have to set up a sidechain.
This doesn't lend itself to manual manipulation because it's not sibilants that you can identify easily, but rather, a reduction of high frequencies if they exceed a certain level.
My main use for sidechaining is effects, like cross-synthesis between instruments, as well as pumping drum sounds for dance mixes.