Hmm again. My WMD Realtek onboard sound constantly makes the same noisy timbre as I get when moving faders with the Saffire, except very loud, and independently of faders*. I don't think that's normal, the sound comes out ok on soundcloud, youtube and such. It's beginning to smell like a fried motherboard circuit to me. Noooo, my trusty old mobo :( well, yeah, maybe not so trusty after all.
*Nevermind this, after further testing, this was only because of a too short buffer size in the driver settings. With a longer buffer, the problem is the same as with the other cards.
I wonder if it could be power supply, or even power bar related, though. In any case, it's settled. I'm selling out, and making cheesy, atrocious pop. Then I'll be rich and when these issues come up I'll just go get a whole damn new setup. HA!