Sounds like a Theremin. Could be synthesized, or the real thing. They've made something or a comeback in the last couple decades. It might even be a sample from some old sci-fi movie soundtrack.
Basically you need to apply an LFO-modulated filter (a.k.a. "wah") to something like a slightly distorted sine wave or a saw with the high frequencies filtered out. Theremins produce a fairly pure tone for the most part.
The good news its that it's really nice and clear in the left channel during the intro. You could almost sample that and make your own instrument but there's some guitar in it.