I have fat fingers, and am constantly PETRIFIED that some errant knuckle bump will launch a nuclear strike. I do not use many of the key bindings, if I do functions repeatedly enough I will learn the ones for those functions, but the sheer number of them means that if my cat jumps on the desk I could end up spending hours trying to undo some changes.
I think my worst fear is that I will end up saving a project with some unknown key bindings having been executed, and then I will agonize over why things start working weirdly.
Bob Bone