I have a spanking new Octacapture and the other day I had a session-destroying time with a guitarist because X2 kept crashing the living daylights out of things. I tried a billion workarounds and even started pulling up DAWs I don't use for audio much anymore (Reaper, Vegas, ACID...) and for various reasons could not get anything happening. Finally, after he had put his stuff away and was getting ready to leave, I pulled up X1 and the session went flawlessly. Same VSTs on every platform.
X2 was 64-bit, X1 is 32. I'm not saying that's what it is but let me tell you sometimes the problem is just not knowable and very frustrating unless you painstakingly choose and burn in every single piece of gear and plugin you use and keep the rig very streamlined. I don't know about the zietgiest of plugins, but I'm returning to a "less is very much more" philosophy and trying to remove anything I don't use all the time to a small and tight rig.